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July 1, 2004Journal of Clinical InvestigationOpen Access

Involvement of chymase-mediated angiotensin II generation in blood pressure regulation

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Population

Mast cell-deficient (Kit(w)/Kit(w-v)) mice and their mast cell-sufficient littermate (MC(+/+)) controls

Comparison

Acute ACE inhibition plus AT(1) receptor blockade vs ACE inhibition alone

Design

Preclinical

Authors

MLMing LiThe Fourth People's HospitalKLKe LiuChina Pharmaceutical UniversityJMJan MichalicekUNSW Sydney

Discussion

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Overview

Suggests mast cell-targeted strategies for hypertension; leaves open translation of dual ACEi/ARB benefit to humans.

Structured PICO

P
Population
Mast cell-deficient (Kit(w)/Kit(w-v)) mice and their mast cell-sufficient littermate (MC(+/+)) controls
I
Intervention
Acute ACE inhibition plus AT(1) receptor blockade
C
Comparator
ACE inhibition alone
O
Outcome
Reduction in mean arterial pressure and ACE-independent Ang II-forming activitysurrogate

Mast cells are the source of the vascular ACE-independent pathway for Angiotensin II generation, providing a mechanistic rationale for the antihypertensive benefit of combining ACE inhibitors with AT1 receptor antagonists.

Cite This Study

Li et al. (2004) studied this question.

synapsesocial.com/papers/6a7d2ca2f1daba58ecd5a9ddhttps://doi.org/10.1172/jci20805
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations1997 · 223 citations
  2. 2Differences in Tissue Angiotensin II–Forming Pathways by Species and Organs In Vitro1998 · 140 citations
  3. 3Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice2001 · 93 citations
  4. 4Synergistic Effects of ACE Inhibition and Ang II Antagonism on Blood Pressure, Cardiac Weight, and Renin in Spontaneously Hypertensive Rats1997 · 137 citations
  5. 5Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.1997 · 219 citations