August 14, 2001Circulation

Functional Evidence for a Role of Vascular Chymase in the Production of Angiotensin II in Isolated Human Arteries

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Population

Isolated human mammary arteries

Comparison

Angiotensin I or chymase-selective substrate… vs Absence of inhibitors or different combinations…

Design

Preclinical

Authors

VRVincent RichardKuban State University SHSonia Hurel-MerleInserm ESElizabeth ScalbertServier (France)

Discussion

Member takes

Implication

Chymase contributes to ACE-independent Ang II formation; leaves open whether selective inhibition offers clinical benefit.

Structured PICO

Population

Isolated human mammary arteries

Intervention

Angiotensin I or chymase-selective substrate [pro,(11) D-Ala(12)] Ang I in the presence of the selective chymase inhibitor C41, captopril, or chymostatin

Comparator

Absence of inhibitors or different combinations of inhibitors

Outcome

Vascular contraction response (as a functional measure of Angiotensin II production)surrogate

This in vitro study provides functional evidence that chymase is a major serine protease responsible for ACE-independent production of Angiotensin II in human arteries.

Cite This Study

Richard et al. (2001) studied this question.

synapsesocial.com/papers/6a8459236b6022c7d8c52f59 https://doi.org/10.1161/hc3201.094971

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Functional Evidence for a Role of Vascular Chymase in the Production of Angiotensin II in Isolated Human Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional Evidence for a Role of Vascular Chymase in the Production of Angiotensin II in Isolated Human Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider