Key result
In human resistance arteries, the combination of enalaprilat and chymostatin almost completely inhibited the contractile response to Ang I, whereas either inhibitor alone had no effect.
Population
Subcutaneous resistance arteries obtained from gluteal biopsies from human volunteers and New Zealand White…
Comparison
Angiotensin I in the presence of enalaprilat 1… vs Angiotensin I alone or single inhibitors
Design
Preclinical
Authors
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Dual blockade may be required for full Ang II suppression in human vessels; leaves open chymase as a therapeutic target.
Human resistance arteries possess a dual pathway for Angiotensin II generation mediated by ACE and a chymostatin-sensitive enzyme (likely chymase), unlike rabbits where ACE is the sole pathway.
Padmanabhan et al. (1999) studied this question. Enalaprilat and chymostatin vs. Enalaprilat alone or chymostatin alone was evaluated on Contractile response to angiotensin I. In human resistance arteries, the combination of enalaprilat and chymostatin almost completely inhibited the contractile response to Ang I, whereas either inhibitor alone had no effect.
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