Population
Human coronary arteries from 25 heart valve donors and porcine coronary arteries from 14 pigs.
Comparison
Angiotensin I and II administration with AT1/AT2… vs Baseline/control responses without inhibitors
Design
Preclinical
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Species differences limit porcine model relevance to human coronaries; leaves open chymase inhibition as a therapeutic target.
This preclinical study demonstrates the functional importance of in situ ACE- and chymase-dependent Angiotensin II generation for vasoconstriction in human coronary arteries.
A 1999 study studied this question.
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