Population
Porcine femoral arteries
Comparison
Angiotensin I and II, in the absence or presence… vs null
Design
Preclinical
Authors
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Interstitial Ang II predominance in animal models warrants tissue ACE studies; leaves open human vasoconstriction relevance.
Interstitial, rather than circulating, Angiotensin II is the primary determinant of vasoconstriction, suggesting local conversion of Ang I by ACE is of greater physiological importance than circulating Ang II.
Schuijt et al. (2002) studied this question.
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