Why the study?
Do ACEI and ARB have blood pressure-independent effects on major cardiovascular events in patients with high blood pressure or elevated cardiovascular risk?
Population
146,838 individuals with high blood pressure or an elevated risk of cardiovascular disease pooled from 26…
Comparison
Angiotensin-converting enzyme inhibitors or… vs Placebo or another drug class
Design
Meta-analysis
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ACEI but not ARB confer BP-independent CHD protection; challenges class equivalence and supports ACEI preference in high-risk hypertension.
Do ACEI and ARB have blood pressure-independent effects on major cardiovascular events in patients with high blood pressure or elevated cardiovascular risk?
ACE inhibitors, but not ARBs, appear to provide blood pressure-independent reductions in the risk of major coronary disease events.
A 2007 study studied this question.
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