The TTX-sensitive Ca2+ current observed in cardiac myocytes under Na+-free conditions is mediated by cardiac Na+ channels, suggesting it should be renamed I(Na(null)).
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Challenges view of cardiac Na+ channels as strictly Na+-selective; leaves open whether I(Ca(TTX)) contributes to Ca2+ dysregulation in vivo.
Guatimosim et al. (2001) studied this question.
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