Key result
In guinea pig ventricular myocytes, mibefradil (10 μmol/L) blocked T-type Ca2+ current by 85±2% and decreased tetrodotoxin-sensitive Ca2+ current by 48±8%.
T-type and TTX-sensitive Ca2+ currents coexist in guinea pig ventricular myocytes and are both blocked by mibefradil, highlighting the need to account for TTX-sensitive components in future studies of T-type currents.
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Requires accounting for TTX-sensitive currents in T-type studies using mibefradil; leaves open its selectivity in cardiac myocyte research.
Heubach et al. (2000) studied None (Basic science). Mibefradil was evaluated on Blockade of I Ca(T) and I Ca(TTX). In guinea pig ventricular myocytes, mibefradil (10 μmol/L) blocked T-type Ca2+ current by 85±2% and decreased tetrodotoxin-sensitive Ca2+ current by 48±8%.
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