Population
Human platelets stimulated with various agonists (in vitro model)
Design
Preclinical
Authors
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May enhance localized anticoagulation on microparticles; leaves open in vivo relevance or therapeutic implications in humans.
Free protein S binds specifically to platelet-derived microparticles, facilitating the binding of protein C and activated protein C, which may play a role in localized anticoagulation.
Wiedmer et al. (1992) studied this question.
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