September 1, 1989HypertensionOpen Access

Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

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Why the study?

Does central neuroadministration of ethanol alter baroreceptor reflex control of heart rate and sympathetic efferent discharge in chloralose-anesthetized rats?

Population

chloralose-anesthetized rats

Comparison

ethanol microinjection into specific brain areas vs injection of ethanol outside of the nucleus…

Design

Preclinical

Authors

XZXiaoling ZhangCincinnati Children's Hospital Medical Center AAAbdel A. Abdel‐RahmanEast Carolina University WWW. R. WoolesMedical University of South Carolina

Discussion

Member takes

Implication

Central ethanol effects on baroreflex and sympathetic activity in rats leave open any human relevance; translational studies required before clinical consideration.

Structured PICO

Does central neuroadministration of ethanol alter baroreceptor reflex control of heart rate and sympathetic efferent discharge in chloralose-anesthetized rats?

Population

chloralose-anesthetized rats

Intervention

ethanol microinjection into specific brain areas (nucleus tractus solitarius, dorsal motor nucleus of the vagus, rostral ventrolateral medulla, posterior hypothalamus, anterior hypothalamus)

Comparator

injection of ethanol outside of the nucleus tractus solitarius, or an equal volume of cerebrospinal fluid

Outcome

acute hemodynamic effects including baseline mean arterial pressure, heart rate, sympathetic efferent discharge, and baroreceptor heart rate responsesurrogate

Ethanol acts centrally in specific hypothalamic and medullary regions to selectively impair baroreceptor heart rate response and increase sympathetic efferent discharge.

Cite This Study

Zhang et al. (1989) studied this question.

synapsesocial.com/papers/6a7db3da603f5e16dd33a043 https://doi.org/10.1161/01.hyp.14.3.282

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Implication

Central ethanol effects on baroreflex and sympathetic activity in rats leave open any human relevance; translational studies required before clinical consideration.

Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider