Why the study?
Does chronic ethanol intake modulate vascular levels of endothelin-1 receptor and enhance the pressor response to endothelin-1 in anaesthetized rats?
Does chronic ethanol intake modulate vascular levels of endothelin-1 receptor and enhance the pressor response to endothelin-1 in anaesthetized rats?
Chronic ethanol consumption increases vascular reactivity to ET-1 and alters ETA and ETB receptor protein levels, which may contribute to ethanol-associated cardiovascular complications.
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Animal data link ethanol to ET-1 hyperreactivity; leaves open relevance to human hypertension or alcohol-related vascular disease.
Tirapelli et al. (2008) studied this question.
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