Why the study?
Does losartan prevent chronic ethanol consumption-induced hypertension and vascular oxidative stress in male Wistar rats?
Does losartan prevent chronic ethanol consumption-induced hypertension and vascular oxidative stress in male Wistar rats?
Chronic ethanol intake increases blood pressure and induces vascular oxidative stress through AT1-dependent mechanisms, which can be prevented by the AT1 receptor antagonist losartan.
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No clinical implications from rat data; leaves open human relevance of AT1 blockade in ethanol hypertension.
Passaglia et al. (2015) studied this question.
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