Why the study?
Does chronic ethanol ingestion increase aortic endothelial nitric oxide synthase expression and NO production in male Sprague Dawley rats?
Population
Male Sprague Dawley rats
Comparison
Isocaloric, Lieber-Decarli liquid diet… vs Isocaloric, Lieber-Decarli liquid diet…
Design
Preclinical
Follow-up
6 weeks
Authors
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Findings in rats warrant caution against human extrapolation; leaves open ethanol's endothelial effects in clinical populations.
Does chronic ethanol ingestion increase aortic endothelial nitric oxide synthase expression and NO production in male Sprague Dawley rats?
Chronic ethanol ingestion for 6 weeks in rats decreases mean arterial pressure and increases aortic NO production and endothelial nitric oxide synthase expression, suggesting a mechanism for alcohol's vascular effects.
Kleinhenz et al. (2007) studied this question.
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