Key result
Treatment with 0.1% ethanol induced a significant increase in NO production and a rapid, two-fold increase in eNOS mRNA expression in endothelial cells.
Why the study?
Does ethanol increase nitric oxide production and eNOS expression in endothelial cells?
Population
Primary cultures of bovine aortic endothelial cells (BAEC) and human umbilical endothelial cells
Design
Preclinical
Follow-up
>24 hours
Authors
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May explain moderate alcohol's endothelial effects in models; hypothesis-generating for human cardioprotection, untested clinically.
Does ethanol increase nitric oxide production and eNOS expression in endothelial cells?
Ethanol increases nitric oxide production and eNOS expression in endothelial cells, suggesting a mechanism for the cardioprotective effects of moderate alcohol consumption.
Venkov et al. (1999) studied this question. Ethanol was evaluated on Endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production. Treatment with 0.1% ethanol induced a significant increase in NO production and a rapid, two-fold increase in eNOS mRNA expression in endothelial cells.
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