Key result
Intragastric ethanol elicited a dose-related increase in NTS NO and reduction in blood pressure in female rats, effects that were dependent on rapid estrogen signaling.
Population
Conscious female rats (sham operated and ovariectomized)
Comparison
Intragastric ethanol with or without estrogen… vs Ovariectomized rats without E2, or vehicle
Design
Preclinical
Follow-up
acute
Authors
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Supports NTS NO role in E2-dependent ethanol hypotension in rats; leaves open clinical translation and human relevance.
Ethanol-induced hypotension in female rats is mediated by an estrogen-dependent enhancement of neuronal NO production in the nucleus tractus solitarius.
Li et al. (2008) studied this question. Intragastric ethanol vs. Ovariectomized rats without estrogen was evaluated on Changes in neuronal NO in NTS neurons, blood pressure, and heart rate. Intragastric ethanol elicited a dose-related increase in NTS NO and reduction in blood pressure in female rats, effects that were dependent on rapid estrogen signaling.
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