Key result
Intragastric ethanol elicited estrogen-dependent decreases in blood pressure in female rats, which resulted mainly from a reduction in cardiac output.
Why the study?
Does intragastric ethanol reduce blood pressure in conscious female rats, and is this effect estrogen-dependent?
Population
Conscious female Sprague-Dawley rats (sham-operated, ovariectomy vehicle-treated, and OVX…
Comparison
Intragastric (i.g.) ethanol vs Equal volume of water
Design
Preclinical
Follow-up
acute
Authors
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Hypothesis-generating for estrogen-alcohol hemodynamics in females; does not support clinical translation or practice change.
Does intragastric ethanol reduce blood pressure in conscious female rats, and is this effect estrogen-dependent?
Intragastric ethanol causes acute hypotension in female rats through a reduction in cardiac output that is strictly dependent on the presence of estrogen.
El‐Mas et al. (1999) studied this question. Intragastric ethanol vs. Equal volume of water was evaluated on Changes in mean arterial pressure, heart rate, cardiac index, stroke volume, total peripheral resistance, and plasma norepinephrine. Intragastric ethanol elicited estrogen-dependent decreases in blood pressure in female rats, which resulted mainly from a reduction in cardiac output.
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