Key result
Ethanol supplementation significantly increased arteriolar density (3.11% vs 1.74%; P=0.004) and myocardial perfusion (1.08 vs 0.585; P=0.014) in swine with chronic myocardial ischemia.
Why the study?
Does ethanol supplementation improve myocardial perfusion and arteriogenesis in a swine model of chronic myocardial ischemia?
Population
16 male Yorkshire swine with chronic myocardial ischemia induced by ameroid constrictor placement into the…
Comparison
90 mL of ethanol (EtOH) daily (50%/V, EtOH) vs 80 g of sucrose of equal caloric value (SUC)
Design
Preclinical
Follow-up
7 weeks
Authors
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Ethanol effects on arteriogenesis remain preclinical; leaves open translation to human coronary disease.
Does ethanol supplementation improve myocardial perfusion and arteriogenesis in a swine model of chronic myocardial ischemia?
Absolute Event Rate: 3.11% vs 1.74%
p-value: p=0.004
Moderate ethanol supplementation promotes arteriogenesis and improves myocardial perfusion in a swine model of chronic ischemia.
Lassaletta et al. (2013) studied Chronic myocardial ischemia (n=16). Ethanol vs. 80 g of sucrose of equal caloric value was evaluated on Arteriolar density (% area of arterioles per low-powered field) (p=0.004). Ethanol supplementation significantly increased arteriolar density (3.11% vs 1.74%; P=0.004) and myocardial perfusion (1.08 vs 0.585; P=0.014) in swine with chronic myocardial ischemia.
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