Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia–reperfusion injury
Why the study?
Does drinking ethanol for 3-12 weeks improve functional recovery and decrease myocyte damage in isolated guinea pig hearts subjected to global ischemia and reperfusion?
Population
Guinea pigs (isolated hearts subjected to global ischemia and reperfusion)
Comparison
Drinking ethanol for 3-12 weeks vs Controls
Design
Preclinical
Follow-up
3-12 weeks
Authors
Discussion
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Member takes
Implication
Does not support ethanol consumption in patients; leaves open A1 receptor pathways for cardioprotection research.
Structured PICO
Does drinking ethanol for 3-12 weeks improve functional recovery and decrease myocyte damage in isolated guinea pig hearts subjected to global ischemia and reperfusion?
P
Population
Guinea pigs (isolated hearts subjected to global ischemia and reperfusion)
I
Intervention
Drinking ethanol for 3-12 weeks
C
Comparator
Controls
O
Outcome
Functional recovery and myocyte damagesurrogate
Long-term ethanol consumption protects guinea pig hearts against ischemia-reperfusion injury via an adenosine A1 receptor-dependent mechanism, mimicking ischemic preconditioning.
Cite This Study
Miyamae et al. (1997) studied this question.