Key result
Chronic moderate and heavy ethanol consumption significantly reduced the recovery of preischemic cardiac external work (30.61% and 29.45%, respectively, vs 65.52% in controls) in isolated rat hearts.
Why the study?
Does chronic moderate or heavy ethanol consumption exacerbate myocardial ischemia/reperfusion injury in a rat model?
Does chronic moderate or heavy ethanol consumption exacerbate myocardial ischemia/reperfusion injury in a rat model?
Absolute Event Rate: 30.61% vs 65.52%
Chronic moderate and heavy ethanol consumption exacerbates myocardial ischemia/reperfusion injury in rats, likely driven by a reduction in postischemic energy status.
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Chronic ethanol may worsen rat I/R recovery; leaves open translation to human cardioprotection.
Gibson et al. (1998) studied Myocardial ischemia/reperfusion injury (n=54). Ethanol consumption vs. 0% calories from ethanol was evaluated on Recovery of preischemic cardiac external work. Chronic moderate and heavy ethanol consumption significantly reduced the recovery of preischemic cardiac external work (30.61% and 29.45%, respectively, vs 65.52% in controls) in isolated rat hearts.
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