Why the study?
Does chronic ethanol consumption impair myocardial mechanical and subcellular function in a rat model?
Population
Rat model of chronic ethanol consumption and pair-fed control rats
Comparison
Chronic ethanol consumption over a 17-week course vs Pair-fed control rats
Design
Preclinical
Follow-up
17 weeks
Authors
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May precede overt dysfunction as early marker in ethanol models; leaves open human translation.
Does chronic ethanol consumption impair myocardial mechanical and subcellular function in a rat model?
Depression of contractile protein function may be an early alcohol-induced derangement in myocardial contractility that precedes the onset of significant mechanical dysfunction.
Hastillo et al. (1980) studied this question.
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