Why the study?
Does chronic ethanol consumption alter excitation-contraction coupling in rat myocardium?
Population
Male Wistar rats
Comparison
40% ethanol and water solution for a 30-week… vs Controls
Design
Preclinical
Follow-up
30 weeks
Authors
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Impairs rat myocardial contractility and APD; leaves open translation to human alcoholic cardiomyopathy.
Does chronic ethanol consumption alter excitation-contraction coupling in rat myocardium?
Chronic ethanol consumption impairs myocardial contractility and alters electrical properties in a rat model, providing insight into the mechanisms of alcoholic cardiomyopathy.
Tepper et al. (1986) studied this question.
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