Why the study?
Does chronic moderate ethanol ingestion alter myocardial mechanical, biochemical, and structural characteristics in male Fischer 344 rats?
Population
Male Fischer 344 rats
Comparison
Chronic ingestion of 30% oral ethanol vs Control (no ethanol)
Design
Preclinical
Follow-up
chronic
Authors
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Should not inform human alcohol guidelines; leaves open translation of myocyte loss to alcoholic cardiomyopathy.
Does chronic moderate ethanol ingestion alter myocardial mechanical, biochemical, and structural characteristics in male Fischer 344 rats?
Chronic moderate alcohol ingestion in rats induces depressed contractile performance, altered enzyme activity, and myocyte loss, which may serve as early indicators of alcoholic heart failure.
Capasso et al. (1992) studied this question.
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