Population
Animal models (rats, mongrel dogs) and in vitro models for studying alcoholic cardiomyopathy
Design
Preclinical
Follow-up
Up to 4 years (in dog models)
Authors
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Supports ethanol cardiotoxicity in dogs; leaves open translation to human alcoholic cardiomyopathy and practice.
Experimental animal models demonstrate that chronic ethanol exposure directly impairs myocardial contractility, diastolic compliance, and calcium handling, providing a mechanistic basis for alcoholic cardiomyopathy.
Regan et al. (1987) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: