Why the study?
Does chronic graded ethanol consumption alter cardiac metabolism, ultrastructure, and mechanical function in rats?
Population
Rats (three sequential sets of ethanolic rats and matched controls)
Comparison
Chronic graded ethanol consumption for 3 to 6… vs Matched controls fed regular chow containing…
Design
Preclinical
Follow-up
3 to 6 months
Authors
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Chronic ethanol is cardiotoxic in rats; extends preclinical models of alcoholic cardiomyopathy but leaves human relevance open.
Does chronic graded ethanol consumption alter cardiac metabolism, ultrastructure, and mechanical function in rats?
Chronic ethanol consumption in rats induces early toxic changes in cardiac microstructure, metabolism, and mechanics, providing insight into the pathogenesis of alcoholic cardiomyopathy.
Segel et al. (1975) studied this question.
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