Why the study?
Does chronic alcohol ingestion induce left ventricular dysfunction and myocyte damage in rats?
Population
Male Fischer 344 rats at 4 months of age
Comparison
30% ethanol in drinking water daily for 8 months vs Age-matched controls
Design
Preclinical
Follow-up
8 months
Authors
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Supports ethanol cardiomyopathy in rats; leaves open translation to human disease.
Does chronic alcohol ingestion induce left ventricular dysfunction and myocyte damage in rats?
Chronic alcohol ingestion in a rat model leads to significant left ventricular dysfunction, structural remodeling, and myocardial damage.
Capasso et al. (1991) studied this question.
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