March 1, 1979Cardiovascular Research

Left ventricular dysfunction of isolated working rat hearts after chronic alcohol consumption

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Why the study?

Does chronic alcohol consumption depress myocardial contractility and pump function in male Long-Evans rats?

Population

Male Long-Evans rats

Comparison

Chronic alcohol consumption for 34 to 48 weeks… vs Isocaloric replacement with dextrin-maltose for…

Design

Preclinical

Follow-up

34 to 48 weeks

Authors

LSLeigh D. SegelUniversity of California, Davis SRS. V. RENDIGUniversity of California, Davis DMD. T. MasonBaylor University Medical Center

Discussion

Member takes

Implication

Chronic alcohol may blunt inotropic response to stress in rat hearts; hypothesis-generating for human alcoholic cardiomyopathy.

Structured PICO

Does chronic alcohol consumption depress myocardial contractility and pump function in male Long-Evans rats?

Population

Male Long-Evans rats

Intervention

Chronic alcohol consumption (nutritionally-complete liquid diet containing 38% of daily calories as ethanol) for 34 to 48 weeks, with either 7.4% (low-fat) or 21.0% (high-fat) of calories from lipid

Comparator

Isocaloric replacement with dextrin-maltose for controls, with either 7.4% (low-fat) or 21.0% (high-fat) of calories from lipid

Outcome

Mechanical, haemodynamic, and energetic functions (ventricular function curves and response to dobutamine during normoxic and hypoxic perfusion)surrogate

Long-term consumption of moderate amounts of alcohol can result in depressed myocardial contractility and pump function under stress conditions in a rat model.

Cite This Study

Segel et al. (1979) studied this question.

synapsesocial.com/papers/6a86c9676fbb37794f7cae65 https://doi.org/10.1093/cvr/13.3.136

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