What is the clinical evidence from this study?

Study design: Observational. Population: Chronic alcoholism without liver disease (n=36). Intervention: Recent alcohol consumption vs. Abstinence (≥1 month) and healthy controls. Primary outcome: Left ventricular performance at rest and during exercise.

October 1, 1987HeartOpen Access

Left ventricular performance in alcoholic patients without chronic liver disease.

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Key result

Recent alcohol consumption in chronic alcoholics without liver disease impairs cardiac contractility and increases afterload during exercise, whereas abnormalities appear reversible after abstinence.

Why the study?

Does abstinence from alcohol improve left ventricular performance in chronic alcoholics without liver disease?

Key Points

The study aims to evaluate left ventricular performance in chronic alcoholics without liver disease and the effects of recent alcohol consumption.
Non-invasive study involving 24 chronic alcoholics divided into two groups based on abstinence duration.
Measured cardiac output, stroke volume, and ejection fraction using multigated radionuclide cardiography during rest and exercise.
Compared hemodynamic variables with 12 healthy controls.
Group A showed similar hemodynamic variables to controls, but left ventricular end systolic volume index did not decrease during exercise.
Group B exhibited increased heart rate and plasma noradrenaline concentrations at rest and exercise, with no significant change in stroke volume during exercise.
End systolic contraction was reduced and diastolic blood pressure was increased in group B patients.

Study Design

Type

Observational (n=36)

Structured PICO

Does abstinence from alcohol improve left ventricular performance in chronic alcoholics without liver disease?

Population

36 participants comprising 24 chronic alcoholics without liver disease (12 abstinent for ≥1 month, 12 recently ceased drinking) and 12 healthy controls.

Exposure

Chronic alcoholism with abstinence for at least one month (Group A) or recent drinking cessation within 24 hours (Group B)

Comparator

Healthy sex and age matched controls

Outcome

Left ventricular performance (cardiac output, stroke volume, left ventricular ejection fraction) measured at rest and during 50% submaximal exercisesurrogate

Cardiac abnormalities in chronic alcoholics without liver disease, such as impaired contractility during stress, may be reversible after at least one month of abstinence.

Discussion

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Implication

Supports possible reversibility of alcohol-related cardiac impairment with abstinence; leaves open need for randomized confirmation.

Cite This Study

Kelbæk et al. (1987) conducted an observational in Chronic alcoholism without liver disease (n=36). Recent alcohol consumption vs. Abstinence (≥1 month) and healthy controls was evaluated on Left ventricular performance at rest and during exercise. Recent alcohol consumption in chronic alcoholics without liver disease impairs cardiac contractility and increases afterload during exercise, whereas abnormalities appear reversible after abstinence.

synapsesocial.com/papers/6a215293589de9df3302f04f https://doi.org/10.1136/hrt.58.4.352

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Left ventricular performance in alcoholic patients without chronic liver disease.

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Left ventricular performance in alcoholic patients without chronic liver disease.

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider