Why the study?
Does long-term alcohol consumption cause progressive cardiac dysfunction in a rat model?
Population
Rats (isolated working hearts from ethanol-fed and control rats)
Comparison
Long-term consumption of alcohol for 2, 4, 7… vs Control rats
Design
Preclinical
Follow-up
Up to 14-16 months
Authors
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Supports rat model of alcohol cardiomyopathy; leaves open translation to human disease and mechanisms.
Does long-term alcohol consumption cause progressive cardiac dysfunction in a rat model?
Long-term alcohol consumption in rats leads to progressive biventricular cardiomegaly and left ventricular dysfunction, with dobutamine sensitivity dependent on nutritional and withdrawal status.
Leigh D. Segel (1988) studied this question.
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