Key result
Chronic ethanol consumption in mice induced an early compensatory phase followed by decompensation toward a dilated heart failure phenotype at 12-14 weeks, with increased hypertrophy and fibrosis.
Why the study?
Does chronic alcohol consumption alter cardiac structure and function in a murine model?
Does chronic alcohol consumption alter cardiac structure and function in a murine model?
Answers are grounded in this paper and cite their sources.
Chronic alcohol consumption in mice leads to an early compensatory phase followed by a transition to a dilated heart failure phenotype associated with myofibroblast activation and fibrosis.
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Law et al. (2012) studied Chronic alcohol consumption. 4% ethanol v/v supplemented liquid diet vs. Isocaloric liquid equivalent and pair fed was evaluated on Changes in cardiac physiology and structure. Chronic ethanol consumption in mice induced an early compensatory phase followed by decompensation toward a dilated heart failure phenotype at 12-14 weeks, with increased hypertrophy and fibrosis.
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