Key result
Chronic ethanol consumption for 2 or 6 weeks caused mild hypertension and increased the contractile response to phenylephrine in the aorta, with effects in the mesenteric arterial bed appearing at 6 weeks.
Why the study?
Does chronic ethanol consumption increase blood pressure and alter vascular reactivity in rats?
Does chronic ethanol consumption increase blood pressure and alter vascular reactivity in rats?
Chronic ethanol consumption in rats induces mild hypertension and alters vascular reactivity in a time- and vessel-dependent manner.
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Should not alter clinical practice; hypothesis-generating for ethanol's vascular effects pending human studies.
Tirapelli et al. (2007) studied this question. Chronic ethanol consumption was evaluated on Blood pressure and vascular reactivity to phenylephrine and acetylcholine. Chronic ethanol consumption for 2 or 6 weeks caused mild hypertension and increased the contractile response to phenylephrine in the aorta, with effects in the mesenteric arterial bed appearing at 6 weeks.
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