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May 1, 1994Hormone and Metabolic Research

Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure

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Why the study?

Does hemodialysis alter plasma concentrations of BNP, ANP, cortisol, and thyroid hormones in patients with chronic renal failure?

Population

30 patients with chronic renal failure undergoing hemodialysis, and 20 control subjects

Comparison

Hemodialysis vs Pre-hemodialysis baseline and healthy controls

Design

Cohort

Follow-up

Duration of a single hemodialysis session

Authors

CHCornelia HaugInsermAMA. MetzeleUniversität UlmJSJ. SteffgenBoehringer Ingelheim (Germany)

Discussion

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Implication

May support BNP/ANP as volume status markers in HD; leaves open prospective validation before guiding therapy.

Structured PICO

Does hemodialysis alter plasma concentrations of BNP, ANP, cortisol, and thyroid hormones in patients with chronic renal failure?

P
Population
30 patients with chronic renal failure undergoing hemodialysis, and 20 control subjects
I
Intervention
Hemodialysis
C
Comparator
Pre-hemodialysis baseline and healthy controls
O
Outcome
Changes in brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) plasma concentrations during hemodialysissurrogate

BNP and ANP plasma concentrations decrease significantly during hemodialysis, supporting their utility as sensitive indicators of extracellular fluid volume status in patients with chronic renal failure.

Cite This Study

Haug et al. (1994) studied this question.

synapsesocial.com/papers/6a7db481cecc27a187a1470fhttps://doi.org/10.1055/s-2007-1001675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes of Plasma Atrial and Brain Natriuretic Peptide Levels During Hemodialysis1996 · 16 citations
  2. 2Effect of haemodialysis on plasma concentrations of atrial natriuretic peptide in adult patients with chronic renal failure1986 · 55 citations
  3. 3Effect of haemodialysis on plasma levels of brain natriuretic peptide in patients with chronic renal failure1992 · 65 citations
  4. 4Changes in Plasma Atrial Natriuretic Peptide during Hemodialysis: Mechanism of Elevated Levels in Patients with Chronic Renal Failure.1993 · 5 citations
  5. 5Plasma Natriuretic Peptides and Cardiac Volume during Acute Changes in Intravascular Volume in Haemodialysis Patients1994 · 40 citations