Maternal cardiovascular adaptation to pregnancy in obese pregnant women
Key result
Obesity during pregnancy was associated with higher blood pressure, heart rate, and cardiac output, altered cardiac geometry (P<0.001), and impaired diastolic indices (P<0.01) compared to normal BMI.
Why the study?
Obesity is linked to cardiovascular compromise and hypertensive disorders in pregnancy, but little is known regarding its effect on maternal cardiac function.
Does obesity alter maternal cardiovascular adaptation and cardiac function during pregnancy compared to normal BMI?
Comparison
Obese pregnant women vs normal BMI pregnant women
Design
Prospective longitudinal study
Follow-up
Up to 30-32 weeks of pregnancy
Authors
Discussion
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Member takes
Implication
May support closer cardiac monitoring in obese pregnancies; hypothesis-generating for links to complications.
Study Design
Type
Cohort (n=73)
Structured PICO
Does obesity alter maternal cardiovascular adaptation and cardiac function during pregnancy compared to normal BMI?
P
Population
73 pregnant women (59 with obesity and 14 with normal BMI) evaluated at 12-14, 20-24, and 30-32 weeks of gestation.
E
Exposure
Obesity (exposure)
C
Comparator
Normal BMI
O
Outcome
Maternal cardiac geometry and function assessed by two-dimensional trans-thoracic echocardiographysurrogate
Main Result
p-value: p=<0.01
Obesity during pregnancy is associated with a hyperdynamic circulation, altered cardiac geometry, and suboptimal diastolic function, which may contribute to increased pregnancy complications.
Cite This Study
Patel et al. (2024) conducted a cohort in Obesity in pregnancy (n=73). Obesity vs. Normal BMI was evaluated on Maternal cardiovascular parameters (blood pressure, heart rate, cardiac output, cardiac geometry, and diastolic function) (p=<0.01). Obesity during pregnancy was associated with higher blood pressure, heart rate, and cardiac output, altered cardiac geometry (P<0.001), and impaired diastolic indices (P<0.01) compared to normal BMI.