January 17, 2023Open Access
Maternal cardiovascular adaptation to pregnancy in obese pregnant women: an observational longitudinal study
Key result
Maternal obesity during pregnancy was associated with higher blood pressure, altered cardiac geometry, and impaired diastolic indices compared to normal BMI (p<0.01 for all).
Why the study?
Obesity is associated with cardiovascular compromise and hypertensive disorders in pregnancy, prompting investigation into its effect on the maternal cardiovascular system.
Does obesity alter maternal cardiovascular adaptation (blood pressure, cardiac geometry, and function) during pregnancy compared to normal BMI?
Population
64 pregnant women with booking BMI ≥ 30kg/m2 and 14 with normal booking BMI (20-24.9kg/m2)
Comparison
Booking BMI ≥ 30kg/m2 vs normal booking BMI (20-24.9kg/m2)
Design
Prospective, observational, longitudinal study
Authors
Discussion
Loading...
Member takes
Implication
Obesity-associated hemodynamic and cardiac changes in pregnancy may heighten complication risk; extends prior data with longitudinal echocardiography but leaves causal links open.
Study Design
Type
Observational (n=78)
Multicenter
No
Structured PICO
Does obesity alter maternal cardiovascular adaptation (blood pressure, cardiac geometry, and function) during pregnancy compared to normal BMI?
P
Population
78 pregnant women (64 with obesity and 14 with normal BMI) evaluated longitudinally for cardiovascular adaptation during pregnancy.
E
Exposure
Obesity (booking BMI ≥ 30kg/m2)
C
Comparator
Normal booking BMI (20-24.9kg/m2)
O
Outcome
Longitudinal difference in blood pressure, cardiac geometry and cardiac function between the groups measured by two-dimensional trans-thoracic echocardiographysurrogate
Main Result
p-value: p=<0.01
Obesity during pregnancy is associated with a hyperdynamic circulation, altered cardiac geometry, and early diastolic dysfunction, which may contribute to increased complication risks.
Cite This Study
Patel et al. (2023) conducted an observational in Pregnancy (n=78). Obesity (BMI ≥ 30kg/m2) vs. Normal BMI (20-24.9kg/m2) was evaluated on Longitudinal difference in blood pressure, cardiac geometry and cardiac function (p=<0.01). Maternal obesity during pregnancy was associated with higher blood pressure, altered cardiac geometry, and impaired diastolic indices compared to normal BMI (p<0.01 for all).