Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339
Key result
Poloxamer 407 is comparable to Triton WR-1339 in determining hepatic triglyceride production in mice, but without the unwanted side effects of Triton.
Authors
Discussion
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Implication
Supports Poloxamer 407 as alternative in murine models; leaves open human translation for hepatic triglyceride assessment.
PICO
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Intervention / Comparator
Poloxamer 407 (P-407) vs Triton WR-1339
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Primary Outcome
Hepatic triglyceride production determination
Cite This Study
Millar et al. (2005) studied this question. Poloxamer 407 (P-407) vs. Triton WR-1339 was evaluated on Hepatic triglyceride production determination. Poloxamer 407 is comparable to Triton WR-1339 in determining hepatic triglyceride production in mice, but without the unwanted side effects of Triton.