Population
Mongrel dogs anesthetized with pentobarbital sodium, pretreated with phenoxybenzamine and propranolol
Comparison
Dopamine infused into the renal artery before… vs Dopamine alone
Design
Preclinical
Authors
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Animal data implicate DA1 receptors in dopamine renal actions; human translation untested and should not change practice.
The study demonstrates that dopamine-induced increases in renal blood flow and electrolyte excretion are mediated by DA1 receptors, not DA2 receptors.
Frederickson et al. (1985) studied this question.
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