Why the study?
Does RNA isolation from whole blood using Catrimox-14 improve detection of HCV RNA compared to plasma in patients with chronic hepatitis?
Population
Individuals with chronic hepatitis, including 15 HCV antibody positive patients and HCV antibody negative…
Comparison
RNA isolation from whole blood using Catrimox-14 vs RNA isolation from plasma and peripheral blood…
Design
Other
Authors
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Whole blood HCV RNA detection may identify cases missed by plasma; hypothesis-generating and requires validation before changing practice.
Does RNA isolation from whole blood using Catrimox-14 improve detection of HCV RNA compared to plasma in patients with chronic hepatitis?
The Catrimox-14 method allows for reliable detection of HCV RNA in whole blood, which may be more sensitive than plasma testing in some patients with chronic hepatitis.
Schmidt et al. (1995) studied this question.
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