Why the study?
Does whole-blood-based RT-PCR improve detection of HCV RNA compared to plasma-based Amplicor assay in patients with chronic liver disease?
Population
50 patients with chronic liver disease
Comparison
Whole-blood-based HCV RNA detection by reverse… vs Plasma-based HCV RNA detection by Roche Amplicor…
Design
Cross-sectional
Authors
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Whole-blood RT-PCR may enhance HCV RNA detection sensitivity; leaves open clinical utility pending prospective validation.
Does whole-blood-based RT-PCR improve detection of HCV RNA compared to plasma-based Amplicor assay in patients with chronic liver disease?
Whole-blood-based HCV RNA detection is significantly more sensitive than plasma-based commercial assays in patients with chronic liver disease.
Stapleton et al. (1999) studied this question.
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