Key result
Type D personality in patients with chronic heart failure was associated with lower Hsp70 levels (6.48 vs 7.85 ng/mL; p=0.04) and an increased oxidative stress ratio compared to non-Type D patients.
Why the study?
Does Type D personality or depression correlate with increased oxidative stress markers in patients with chronic heart failure?
Population
122 patients with chronic heart failure (CHF)
Comparison
Type D (distressed) personality and depression vs Non-Type D personality and absence of depression
Design
Cross-sectional
Authors
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Supports oxidative stress link in Type D chronic HF; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=122)
Does Type D personality or depression correlate with increased oxidative stress markers in patients with chronic heart failure?
Standardized Mean Difference: 0.26
Absolute Event Rate: 6.48% vs 7.85%
p-value: p=.04
Type D personality in chronic heart failure patients is associated with an increased oxidative stress burden, providing a potential mechanism for the adverse prognosis observed in emotionally distressed patients.
Kupper et al. (2009) conducted a cross-sectional in Chronic Heart Failure (n=122). Type D personality vs. non-Type D personality was evaluated on Serum levels of inducible heat shock protein (Hsp)70 (d = 0.26, p=.04). Type D personality in patients with chronic heart failure was associated with lower Hsp70 levels (6.48 vs 7.85 ng/mL; p=0.04) and an increased oxidative stress ratio compared to non-Type D patients.
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