Key result
Curcumae Rhizoma substantially decreased myocardial fibrosis and recovered cardiac function in ISO-induced rats by inhibiting p38 MAPK/NF-κB and TGF-β1/Smad2/3 pathways.
Why the study?
Curcumae Rhizoma has been used to treat cardiovascular illnesses, but its role and potential mechanisms in myocardial fibrosis remain unknown.
Curcumae Rhizoma attenuates myocardial fibrosis and improves cardiac function in a rat model, potentially via inhibition of p38 MAPK/NF-κB and TGF-β1/Smad2/3 pathways.
May support Curcumae Rhizoma for myocardial fibrosis in preclinical models; leaves open clinical efficacy pending trials.
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Zhang et al. (2022) studied Myocardial fibrosis. Curcumae Rhizoma was evaluated on Myocardial fibrosis and cardiac function. Curcumae Rhizoma substantially decreased myocardial fibrosis and recovered cardiac function in ISO-induced rats by inhibiting p38 MAPK/NF-κB and TGF-β1/Smad2/3 pathways.
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