Key result
Gui-Qi-Yang-Xin Decoction alleviates isoproterenol-induced myocardial fibrosis in rats and cells by modulating PTGS2, MAPK, and AKT1.
Why the study?
Gui-Qi-Yang-Xin Decoction exerts therapeutic effects on myocardial fibrosis, but its bioactive compounds and underlying pharmacological mechanisms remain to be elucidated.
Population
Isoproterenol-induced myocardial fibrosis rats and H9C2 cells
Comparison
Gui-Qi-Yang-Xin Decoction vs controls
Design
Network pharmacology study with in vivo animal and in vitro cell experimental validation
Authors
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Supports preclinical exploration of GQYXD in myocardial fibrosis; leaves open clinical translation in humans.
Gui-Qi-Yang-Xin Decoction alleviates myocardial fibrosis in preclinical models via modulation of PTGS2, MAPK14, MAPK8, and AKT1 pathways.
Jiang et al. (2022) studied Myocardial fibrosis (n=90). Gui-Qi-Yang-Xin Decoction (GQYXD) vs. Isoproterenol-induced model group was evaluated on Myocardial fibrosis alleviation and regulation of PTGS2, MAPK14, AKT1, and MAPK8 expression. Gui-Qi-Yang-Xin Decoction alleviated isoproterenol-induced myocardial fibrosis in rats and H9C2 cells by down-regulating PTGS2, MAPK14, and MAPK8, and up-regulating AKT1 expression.
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