Key result
Qishen Granule suppressed splenic monocyte recruitment via the Ang II/AT1-MCP-1/CCR2 pathway and promoted angiogenesis by shifting M1 to M2 macrophages.
Why the study?
The detailed effects of Qishen Granule on the recruitment and differentiation of macrophages under ischemic conditions had not been elucidated.
Comparison
Qishen Granule treatment
Authors
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Hypothesis-generating for Qishen Granule in post-MI repair; clinical trials needed before any therapeutic consideration.
Qishen Granule attenuates myocardial remodeling under ischemic conditions by regulating monocyte recruitment and promoting M2 macrophage differentiation.
Wen-ji et al. (2019) studied Myocardial remodeling. Qishen Granule (QSG) was evaluated on Release of splenic monocytes, recruitment to heart tissues, and macrophage differentiation. Qishen Granule suppressed splenic monocyte recruitment via the Ang II/AT1-MCP-1/CCR2 pathway and promoted angiogenesis by shifting M1 to M2 macrophages.
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