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September 5, 2017Journal of the Chinese Medical Association

Danggui Buxue decoction promotes angiogenesis by up-regulation of VEGFR1/2 expressions and down-regulation of sVEGFR1/2 expression in myocardial infarction rat

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Key result

Danggui Buxue decoction accelerated cardiac angiogenesis, restrained fibrous scar formation, and ameliorated cardiac function in post-MI rats via regulation of the VEGF/VEGFRs signaling pathway.

Why the study?

Does Danggui Buxue decoction improve cardiac function and promote angiogenesis in a rat model of myocardial infarction?

Population

SD Rats with ligation of left anterior descending (LAD) coronary artery (myocardial infarction model)

Comparison

Danggui Buxue decoction high dose or low dose… vs Untreated MI rats, MI plus Betaloc Zok, and…

Design

Preclinical, randomly divided

Follow-up

4 weeks

Authors

GHGuanying HuPYPeng YangYZYu Zeng

Discussion

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Member takes

Overview

Does not support clinical use post-MI; leaves open translation of VEGF-mediated repair from rat models.

Structured PICO

Does Danggui Buxue decoction improve cardiac function and promote angiogenesis in a rat model of myocardial infarction?

P
Population
SD rats with LAD ligation-induced myocardial infarction treated for 4 weeks.
I
Intervention
Danggui Buxue decoction (DBD) high dose or low dose for 4 consecutive weeks
C
Comparator
Untreated MI rats, MI plus Betaloc Zok, and sham-operated rats
O
Outcome
Cardiac function evaluated by hemodynamics, cardiac histological morphology, microvascular density, and expressions of VEGF and VEGFR1/2 mRNA and relative proteinssurrogate

Danggui Buxue decoction improves post-myocardial infarction cardiac function and remodeling in rats by promoting angiogenesis through the VEGF/VEGFRs signaling pathway.

Cite This Study

Hu et al. (2017) studied Myocardial infarction. Danggui Buxue decoction (DBD) vs. MI group, MI plus Betaloc Zok, and sham-operated group was evaluated on Cardiac function, fibrotic scar formation, microvascular density, and VEGF/VEGFR expressions. Danggui Buxue decoction accelerated cardiac angiogenesis, restrained fibrous scar formation, and ameliorated cardiac function in post-MI rats via regulation of the VEGF/VEGFRs signaling pathway.

synapsesocial.com/papers/6a6d5f41a528af2d65c29f0fhttps://doi.org/10.1016/j.jcma.2017.06.015
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