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October 1, 1995BloodOpen Access

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

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Population

Human CD34+ bone marrow and cord blood cells in vitro

Comparison

Recombinant human thrombopoietin in the presence… vs TPO alone, interleukin-3, granulocyte/macrophage…

Design

Preclinical

Authors

MKMasao KobayashiHigashi Osaka City General HospitalJLJH LaverMedical University of South CarolinaTKTakashi KatoVascular Medicine

Discussion

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Implication

Animal data only; leaves open any therapeutic role for TPO in human erythropoiesis.

Structured PICO

P
Population
Human CD34+ bone marrow and cord blood cells in vitro
I
Intervention
Recombinant human thrombopoietin (TPO, Mpl ligand) in the presence of erythropoietin
C
Comparator
TPO alone, interleukin-3, granulocyte/macrophage colony-stimulating factor, steel factor, or soluble Mpl receptor
O
Outcome
Erythroid burst formationsurrogate

TPO exhibits burst-promoting activity for erythroid progenitors in vitro when combined with erythropoietin, mediated via the Mpl receptor.

Cite This Study

Kobayashi et al. (1995) studied this question.

synapsesocial.com/papers/6a7dc44afd5c83ea4ea1427chttps://doi.org/10.1182/blood.v86.7.2494.2494
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Also Consider

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  1. 1Purification and Characterization of Thrombopoietin11995 · 249 citations
  2. 2Thrombocytopenia in c-mpl-deficient mice1994 · 690 citations
  3. 3Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.1990 · 1,038 citations
  4. 4Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.1988 · 288 citations
  5. 5M‐07e human leukemic factor‐dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM‐CSF and IL‐31990 · 141 citations