Quinacrine (Atabrine®) in the Treatment of Neoplastic Effusions

Article1 February 1967Quinacrine (Atabrine®) in the Treatment of Neoplastic EffusionsMALIN R. DOLLINGER, M.D., IRWIN H. KRAKOFF, M.D., F.A.C.P., DAVID A. KARNOFSKY, M.D., F.A.C.P.MALIN R. DOLLINGER, M.D.Search for more papers by this author, IRWIN H. KRAKOFF, M.D., F.A.C.P.Search for more papers by this author, DAVID A. KARNOFSKY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-2-249 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptQuinacrine (Atabrine®) inhibited the growth of several transplanted solid tumors (1) and of the Ehrlich ascites tumor in mice (when it was given intraperitoneally) (2). It was cytotoxic to a variety of normal and tumor cells grown in tissue culture (3). In a variety of experimental tumors and in man cytotoxic levels comparable to those effective against tumor cells in tissue culture could not be achieved without unacceptable host toxicity. By local instillation into serous cavities, high local concentrations of quinacrine were obtained. When used clinically, it was found by Gellhorn, Zaidenweber, Ultmann, and Hirschberg (2) and by Ultmann, Gellhorn,...References1. VASSEYEDMONDSIRVINGREENIRVIN JWJJLJAEM: Studies on the administration of quinacrine to tumor-bearing mice. Cancer Res. 15: 573, 1955. MedlineGoogle Scholar2. GELLHORNZAIDENWEBERULTMANNHIRSCHBERG AJJE: The use of atabrine (quinacrine) in the control of recurrent neoplastic effusions. A preliminary report. Dis. Chest 39: 165, 1961. CrossrefMedlineGoogle Scholar3. HIRSCHBERGGELLHORNREINEREISINGMURRAY EALRFMR: In vivo and in vitro effects of quinacrine and related acridines on human and mouse brain tumors. Proc. Amer. Ass. Cancer Res. 2: 117, 1956. Google Scholar4. ULTMANNGELLHORNOSNOSHIRSCHBERG JEAME: The effect of quinacrine on neoplastic effusions and certain of their enzymes. Cancer 16: 283, 1963. CrossrefMedlineGoogle Scholar5. ROCHLINSMARTWAGNERSILVA DBCRDEAR: The control of recurrent malignant effusions using quinacrine hydrochloride. Surg. Gynec. Obstet. 118: 991, 1964. MedlineGoogle Scholar6. KARNOFSKYELLISONGOLBEY DARRRB: Selection of patients for evaluation of chemotherapeutic procedures in advanced cancer. J. Chronic Dis. 15: 243, 1962. CrossrefMedlineGoogle Scholar7. MATEO-TORRESCINTRÓN-RIVERA FAA: The value of Wright's stain in the cytological study of effusions. Clin. Res. 14: 359, 1966. Google Scholar8. : An agent for the palliative treatment of neoplastic effusions. Quinacrine (atabrine) hydrochloride. JAMA 195: 161, 1966. CrossrefMedlineGoogle Scholar9. CLARKSON B: Relationship between cell type, glucose concentration, and response to treatment in neoplastic effusions. Cancer 17: 914, 1964. CrossrefMedlineGoogle Scholar10. BRILMAYERKOHLERMACKSTORDEUR CAAK: Die Affinität bestimmter Farbstoffe zum gesunden und neoplastischen Gewebe, geprüft durch quantitative Gewebsextraktionen. Z. Krebsforsch. 60: 334, 1955. CrossrefMedlineGoogle Scholar11. WEISSBERG M: Resorption und Ausscheidung fluorescierender Substanzen. Z. Krebsforsch. 62: 668, 1959. CrossrefMedlineGoogle Scholar12. YOUNGWILDSIMON-REUSS JMFI: Studies of the uptake of tritium labelled mepacrine by tumours. Brit. J. Cancer 19: 370, 1965. CrossrefMedlineGoogle Scholar13. ACKERMANSHEMESH NBA: Localization of aminoacridine fluorescence in lung tumors of rats. JAMA 187: 832, 1964. CrossrefMedlineGoogle Scholar14. WHITEHOUSEBOSTRÖM MWH: Biochemical properties of anti-inflammatory drugs. VI. The effects of chloroquin (resochin), mepacrine (quinacrine) and some of their potential metabolites on cartilage metabolism and oxidative phosphorylation. Biochem. Pharmacol. 14: 1173, 1965. CrossrefMedlineGoogle Scholar15. GOODMANGILMAN LSA: The Pharmacological Basis of Therapeutics, 2nd ed. The Macmillan Co., New York, 1956, pp. 1167-1173. Google Scholar16. HEMKERHÜLSMANN HCWC: Inhibition of enzymes by atebrin. Biochim. Biophys. Acta 44: 175, 1960. CrossrefMedlineGoogle Scholar17. KURNICKRADCLIFFE NBIE: Reaction between DNA and quinacrine and other antimalarials. J. Lab. Clin. Med. 60: 669, 1962. MedlineGoogle Scholar18. LERMAN LS: Acridine mutagens and DNA structure. J. Cell. Comp. Physiol. 64 (suppl. 1): 1, 1964. CrossrefMedlineGoogle Scholar19. REINERGELLHORN LA: Localization of drugs within cells. Binding of quinacrine by liver cell constituents. J. Pharmacol. Exp. Ther. 117: 52, 1956. MedlineGoogle Scholar20. MCKIBBINGAZETHOPPESCHWAB BJEC: Chemical irrigation of wounds inoculated with cancer cells. Arch. Surg. (Chicago) 87: 877, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Division of Clinical Chemotherapy, Sloan-Kettering Institute for Cancer Research, the Department of Medicine, Memorial and James Ewing Hospitals and Cornell University Medical College, New York, N. Y.This study was supported by grants CA-03215, CA-05826, CA-08748, CA-17066, and T1 CA-5110-04, U. S. Public Health Service, Washington, D. C.At the time of this study Dr. Dollinger was a Fellow supported by grant 1-F3-CA-32,812-01, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Malin R. Dollinger, M.D., 444 E. 68th St., New York, N. Y. 10021. 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