Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Daniela Adamo; Elena Calabria; Federica Canfora; Noemi Coppola; Stefania Leuci; Martina Mignogna; Lorenzo Lo Muzio; Francesca Spirito; Michele Giuliani; Lorenzo Azzi; Marta Dani; Giuseppe Colella; Chiara Colella; Lucio Montebugnoli; Davide Bartolomeo Gissi; Mario Gabriele; Marco Nisi; Andrea Sardella; Giovanni Lodi; Elena Maria Varoni; Amerigo Giudice; Alessandro Antonelli; Alessio Gambino; Giuliana Antonucci; Paolo Vescovi; Marco Meleti; Alessandra Majorana; Elena Bardellini; Giuseppina Campisi; Vera Panzarella; F. Spadari; U. Garagiola; Monica Pentenero; Samuele Sutera; Matteo Biasotto; Giulia Ottaviani; Margherita Gobbo; Luca Guarda‐Nardini; Umberto Romeo; Gianluca Tenore; R Serpico; Alberta Lucchese; Carlo Lajolo; Gioele Gioco; Massimo Aria; Luca D’Aniello; Michele Davide Mignogna

doi:10.1007/s00784-023-04909-3

February 14, 2023Clinical Oral InvestigationsOpen Access

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

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Key Points

To evaluate the prevalence of anxiety and depression in patients with keratotic oral lichen planus (K-OLP) and identify potential predictors affecting mental health status.
Recruited 300 patients with K-OLP and 300 healthy controls across 15 Italian universities.
Administered the Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A).
Analyzed psychological predictors using linear correlation assessments and multivariate logistic regression models.
Anxiety and depression were detected in 158 (52.7%) and 148 (49.3%) of K-OLP patients, respectively, at significantly higher frequencies than in healthy controls.
Linear correlations emerged between psychological scores (HAM-A, HAM-D), pain indices (NRS, T-PRI), female gender, and employment status.
Multivariate logistic regression demonstrated that HAM-D and HAM-A accounted for the greatest variance increases for anxiety (ΔR² = 55.5%, p < 0.001) and depression (ΔR² = 56.5%, p < 0.001), persisting even among pain-free patients.

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Implication

Multicenter case-control study reveals elevated anxiety and depression in keratotic oral lichen planus, indicating psychological distress occurs independently of physical pain.

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Cite This Study

Adamo et al. (2023) studied this question.

synapsesocial.com/papers/6a7dcc29c2b228f3e18ca118 https://doi.org/10.1007/s00784-023-04909-3

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Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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