What question did this study set out to answer?

To examine whether major extracellular matrix proteins are expressed differently in the left atrial tissue of patients with sinus rhythm, lone atrial fibrillation, and atrial fibrillation with underlying mitral valve disease.

March 12, 2004HeartOpen Access

Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease

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Why the study?

Are major extracellular matrix proteins expressed differently in the left atrial tissue of patients with lone AF, AF with mitral valve disease, and sinus rhythm?

Population

118 patients with lone atrial fibrillation, AF with underlying mitral valve disease, and sinus rhythm

Design

Case-control

Authors

ABAndreas BoldtLeipzig University

Discussion

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Implication

Suggests differential atrial fibrosis patterns across AF subtypes; extends observational data but leaves causal and therapeutic roles open.

Key Points

To examine whether major extracellular matrix proteins are expressed differently in the left atrial tissue of patients with sinus rhythm, lone atrial fibrillation, and atrial fibrillation with underlying mitral valve disease.
Case-control study involving 118 patients categorized into lone atrial fibrillation (AF), AF with underlying mitral valve disease (MVD+AF), and sinus rhythm (SR).
Left atrial tissue expression of collagen I, collagen III, and fibronectin was quantified using western blotting and immunohistochemical techniques.
Patients with AF displayed significantly higher total concentrations than those in SR for collagen I (1.15 [0.11] vs 0.45 [0.28], p = 0.002) and collagen III (0.74 [0.05] vs 0.46 [0.11], p = 0.002), whereas fibronectin did not reach significance (0.88 [0.06] vs 0.62 [0.13], p = 0.08).
Collagen I was similarly elevated in lone AF (1.49 [0.15]) and MVD+AF (1.53 [0.16]) versus SR (0.56 [0.28], both p = 0.01), while collagen III was selectively elevated in MVD+AF (0.84 [0.07] vs 0.46 [0.11], p = 0.01) but not in lone AF.
Collagen expression was enhanced to a similar degree between paroxysmal AF and chronic AF.

Structured PICO

Are major extracellular matrix proteins expressed differently in the left atrial tissue of patients with lone AF, AF with mitral valve disease, and sinus rhythm?

Population

118 patients with lone atrial fibrillation (AF), AF with underlying mitral valve disease (MVD+AF), and sinus rhythm (SR)

Comparator

Patients in sinus rhythm (SR)

Outcome

Collagen I, collagen III, and fibronectin protein expression measured by quantitative western blotting techniques and immunohistochemical methodssurrogate

Atrial fibrillation is associated with increased left atrial fibrosis, with different forms of AF showing variations in collagen III expression, suggesting a role for extracellular matrix proteins in structural remodeling.

Cite This Study

Andreas Boldt (2004) studied this question.

synapsesocial.com/papers/6a7dce3e019fe016aa339886 https://doi.org/10.1136/hrt.2003.015347

Topics

Atrial fibrillation Persistent AF management Valvular heart disease

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Implication

Suggests differential atrial fibrosis patterns across AF subtypes; extends observational data but leaves causal and therapeutic roles open.

Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider