Key result
This review highlights that central thermoregulatory control reflects neural control of body temperature, whereas peripheral control reflects properties specific to thermoeffector organs.
Why the study?
Traditional evaluation of thermoregulatory control interprets onset threshold and thermosensitivity changes as central versus peripheral modulation, but the strengths, weaknesses, and validity of this approach required re-examination.
This review clarifies the physiological interpretation of central versus peripheral thermoregulatory control and advocates for more direct investigative methods.
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Distinguishes central neural from peripheral effector thermoregulation; leaves open direct mechanistic studies in cardiovascular contexts.
Human thermoregulatory control is often evaluated through the relationship between thermoeffector output and core or mean body temperature. In addition to providing a general indication of whether a variable of interest alters thermoregulatory control, this relationship is often used to determine how this alteration may occur. This latter interpretation relies upon two parameters of the thermoeffector output-body temperature relationship: the onset threshold and thermosensitivity. Traditionally, changes in the onset threshold and thermosensitivity are interpreted as "central" or "peripheral" modulation of thermoregulatory control, respectively. This mini-review revisits the origins of the thermoeffector output-body temperature relationship and its use to interpret "central" or "peripheral" modulation of thermoregulatory control. Against this background, we discuss the strengths and weaknesses of this approach and highlight that "central" thermoregulatory control reflects the neural control of body temperature whereas "peripheral" thermoregulatory control reflects properties specific to the thermoeffector organs. We highlight studies that employed more direct approaches to investigate the neural control of body temperature and peripheral properties of thermoeffector organs. We conclude by encouraging future investigations interested in studying thermoregulatory control to more directly investigate the component of the thermoeffector loop under investigation.heat; human; skin blood flow; sweat; thermoregulatory.
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Ravanelli et al. (2021) conducted a review in Thermoregulatory control. This review highlights that central thermoregulatory control reflects neural control of body temperature, whereas peripheral control reflects properties specific to thermoeffector organs.
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