Why the study?
Does a brief period of ischemia and reperfusion alter the responsiveness of inhibitory G proteins during a subsequent ischemic event in a canine model?
Population
47 anesthetized dogs
Comparison
Acute myocardial ischemia induced by proximal… vs Posterior left ventricular wall
Design
Preclinical
Follow-up
Up to 60 minutes of reperfusion
Authors
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May implicate inhibitory G proteins in canine preconditioning; leaves open translation to human cardioprotection.
Does a brief period of ischemia and reperfusion alter the responsiveness of inhibitory G proteins during a subsequent ischemic event in a canine model?
The protective mechanism of ischemic preconditioning may be driven by an increased responsiveness of inhibitory G proteins following a brief initial period of ischemia and reperfusion.
Niroomand et al. (1995) studied this question.
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