Why the study?
Does reserpine treatment reduce arrhythmogenesis during ischaemia and reperfusion in isolated rat hearts?
Population
Isolated rat heart preparation
Design
Preclinical
Authors
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Supports noradrenaline depletion in attenuating rat ischemia-reperfusion arrhythmias; leaves open clinical translation or human trials.
Does reserpine treatment reduce arrhythmogenesis during ischaemia and reperfusion in isolated rat hearts?
In an isolated rat heart model, reserpine-induced depletion of myocardial catecholamines significantly attenuated arrhythmias during ischaemia and reperfusion.
Zhan et al. (1989) studied this question.
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