Why the study?
Does long-term reserpine therapy alter cardiac output and atrioventricular conduction in men with essential hypertension?
Population
8 men with previously untreated essential hypertension
Comparison
Long-term reserpine therapy for 20 to 205 days vs Pre-reserpine baseline (intra-patient comparison)
Design
Cohort
Follow-up
20 to 205 days
Authors
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May heighten conduction block risk during tachycardia in treated hypertensives; hypothesis-generating and requires randomized confirmation before clinical consideration.
Does long-term reserpine therapy alter cardiac output and atrioventricular conduction in men with essential hypertension?
Long-term reserpine therapy in hypertensive men significantly lowers cardiac output and increases A-V conduction, potentially enhancing second-degree heart block during tachycardia.
Cohen et al. (1968) studied this question.
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